Endocrine Abstracts

Introduction: Thyroid hormones (TH) are essential regulators of metabolism and increase energy expenditure (EE). Mitochondria-rich brown adipose tissue (BAT) is specialised in thermogenesis and significantly contributes to EE. BAT contains essential components of TH action but TH transporters like MCT8 have not been characterised so far. As direct effects on O2 consumption and mitochondrial action have not been investigated before we tested MCT8 expression and direct effects o...

Objective: Abnormal mitochondria are well known in oxyphilic thyroid tumors but recent data also confirm profound mitochondrial alterations in other thyroid carcinomas. These changes are linked to the aggressiveness of the tumors. Our group recently demonstrated in an in vivo model, that inhibition of phosphoinositide 3-kinase (PI3K) signalling suppressed the invasive and metastatic behaviour of thyroid cancer cells. Here, we evaluated whether a modulation of PI3K sig...